https://doi.org/10.1007/s00392-025-02625-4
1Universitätsklinikum Leipzig Klinik und Poliklinik für Kardiologie Leipzig, Deutschland; 2Universitätsklinikum Köln Poliklinik für Endokrinologie, Diabetologie und Präventivmedizin Köln, Deutschland; 3Universitätsklinikum Jena Klinik für Innere Medizin I - Kardiologie Jena, Deutschland; 4Charité - Universitätsmedizin Berlin Medizinische Klinik für Endokrinologie und Stoffwechselmedizin Berlin, Deutschland; 5Universitätsklinikum Carl Gustav Carus an der TU Dresden Medizinische Klinik & Poliklinik III Dresden, Deutschland
Methods
Results
Conclusions
Table
|
Total (n=1111) |
Self-medication (n=747) |
No self-medication (n=364) |
P
|
Demographic data |
|
|
|
|
Age (years) |
66.1 (9.9) |
66.0 (9.7) |
66.2 (10.9) |
0.81 |
Female |
57.7 |
61.2 |
50.3 |
0.001 |
Laboratory parameters (mmol/L) |
|
|
|
|
Total cholesterol |
4.8 (1.7) |
4.8 (1.7) |
4.9 (1.7) |
0.80 |
LDL cholesterol |
2.8 (1.5) |
2.8 (1.5) |
2.8 (1.6) |
0.72 |
HDL cholesterol |
1.5 (0.5) |
1.5 (0.4) |
1.5 (0.5) |
0.42 |
Triglycerides |
1.8 (1.1) |
1.8 (1.1) |
1.8 (1.0) |
0.43 |
Lipid-lowering agents |
|
|
|
|
Established lipid-lowering therapy |
83.4 |
83.7 |
82.8 |
0.72 |
Statin |
26.9 |
24.9 |
31.0 |
0.03 |
Ezetimibe |
39.2 |
36.3 |
45.1 |
0.005 |
Bempedoic acid |
25.4 |
25.3 |
25.6 |
0.93 |
PCSK9 inhibitor |
48.0 |
51.1 |
41.5 |
0.003 |
Cardiovascular risk factors |
|
|
|
|
Hypertension |
75.2 |
77.0 |
71.7 |
0.06 |
Diabetes |
19.1 |
20.4 |
16.6 |
0.13 |
Active smoking |
10.0 |
11.0 |
8.0 |
0.12 |
ASCVD |
88.0 |
87.2 |
90.1 |
0.16 |
Comorbidities |
|
|
|
|
Orthopedic disease |
53.0 |
57.7 |
43.2 |
<0.001 |
Depression |
10.3 |
12.1 |
6.6 |
0.005 |
Allergy |
43.2 |
45.5 |
38.3 |
0.04 |
Chronic kidney disease |
13.4 |
13.7 |
12.9 |
0.73 |
Psycho-social |
|
|
|
|
EQ VAS score |
64.8 (12.1) |
62.6 (18.5) |
70.0 (16.1) |
<0.001 |
PHQ-9 score |
5.8 (4.4) |
6.4 (4.7) |
3.4 (4.3) |
<0.001 |
In committed relationship |
73.5 |
77.0 |
66.5 |
<0.001 |
Higher education |
20.6 |
21.6 |
18.7 |
0.27 |
Other parameters of interest |
|
|
|
|
Intensity of muscle pain while on statin |
7.0 (1.8) |
7.1 (1.7) |
6.7 (1.9) |
0.001 |
SAMS-CI score |
9.0 (1.8) |
9.0 (1.8) |
8.9 (1.9) |
0.67 |
Expectation of adverse events on statin |
6.0 |
7.1 |
3.9 |
0.03 |
Acquaintances with statin intolerance |
36.6 |
42.4 |
23.9 |
<0.001 |
Figure 1
Figure 2